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Updated: May 9, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
Complications of prostate biopsy
Anastasios Anastasiadis1, Lukasz Zapała, Ernesto Cordeiro
1Department of Urology, AMC University Hospital, Meibergdreef 9,1105 Amsterdam, The Netherlands.
Prostate biopsy complications, though infrequent, affect many men globally. This review details managing bleeding and infectious risks, noting ciprofloxacin resistance as a growing concern for prostate biopsy safety.
Area of Science:
- Urology
- Medical Complications
- Patient Safety
Background:
- Prostate biopsy is a common diagnostic procedure worldwide.
- While generally safe, complications can occur and impact patient health.
- The cumulative number of patients experiencing complications is clinically significant.
Purpose of the Study:
- To review the diagnosis and management of complications following prostate biopsy.
- To highlight common and rare adverse events associated with the procedure.
- To inform healthcare professionals on best practices for managing post-biopsy issues.
Main Methods:
- Literature review focusing on post-prostate biopsy complications.
- Analysis of reported incidence, diagnosis, and treatment strategies.
- Synthesis of current understanding regarding bleeding and infectious risks.
Main Results:
- Bleeding is the most frequent complication; use of NSAIDs or aspirin is not an absolute contraindication.
- Increasing antibiotic resistance, particularly to ciprofloxacin, is linked to higher infectious complication rates.
- Extremely rare fatal complications have been documented in case reports.
Conclusions:
- Effective management strategies are crucial for addressing prostate biopsy complications.
- Awareness of emerging antibiotic resistance is vital for preventing infectious sequelae.
- While rare, the potential for severe outcomes necessitates careful patient monitoring and procedural care.
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