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Long non-coding RNAs and their implications in cancer epigenetics
Felipe C Beckedorff1, Murilo Sena Amaral, Carlos Deocesano-Pereira
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.
Bioscience Reports
|July 24, 2013
Summary
Long non-coding RNAs (lncRNAs) regulate gene expression and epigenetic processes. This review explores their role in cancer, highlighting their potential as diagnostic markers and therapeutic targets.
Area of Science:
- Molecular Biology
- Epigenetics
- Cancer Research
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression.
- LncRNAs participate in epigenetic processes, influencing chromatin structure and gene control.
- Dysregulation of epigenetic marks is linked to cancer development.
Purpose of the Study:
- To review the involvement of lncRNAs in the epigenetic control of gene expression in cancer.
- To discuss the potential of lncRNAs as diagnostic markers and therapeutic targets in oncology.
Main Methods:
- Literature review focusing on lncRNAs, epigenetics, and cancer.
- Analysis of current understanding of lncRNA functions in epigenetic regulation.
- Synthesis of evidence linking lncRNA misregulation to cancer phenotypes.
Main Results:
- LncRNAs are implicated in epigenetic mechanisms controlling gene expression relevant to cancer.
- Altered expression patterns of many cancer-associated lncRNAs are documented.
- Few lncRNAs are identified as prognostic markers for cancer survival.
Conclusions:
- LncRNAs play significant roles in cancer through epigenetic regulation.
- LncRNAs exhibit tissue-specific properties, making them potential diagnostic markers.
- Further research into lncRNA-protein and lncRNA-DNA interactions may yield novel cancer therapies.
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02:39lncRNA - Long Non-coding RNAs
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01:37Epigenetic Regulation
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01:46Epigenetic Regulation
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Overview
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