Synthetic glycopolypeptides as biomimetic analogues of natural glycoproteins
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Colin Bonduelle1, Sébastien Lecommandoux
1Université de Bordeaux /IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France.
Abstract:
Glycoproteins are naturally produced by protein glycosylation and are involved in a wide range of cellular functions. This Review aims to summarize the preparation of well-defined synthetic glycoproteins by using chemical routes as well as to highlight the preparation of ideal polymeric analogues of natural glycoproteins: glycopolypeptides. These macromolecules are simplified models of glycoproteins and are designed with the purpose of both mimicking the properties of natural glycoproteins as well as bringing innovative polymeric structures for materials science applications.
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