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Updated: May 9, 2026
10:12
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
Published on: October 31, 2012
[Fetal taking in some particular circumstances].
P Roth1, J-P Bernard, L J Salomon
1Service de maternité, CPDPN, hôpital universitaire Necker-Enfants-malades, Paris, France. philippe.roth@nck.aphp.fr
Gynecologie, Obstetrique & Fertilite
|July 24, 2013
Summary
Fetal sampling, concerning 6-7% of pregnancies, can be complicated by maternal factors like anticoagulation or fever. This study provides guidelines for managing difficult fetal sampling in high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
- Prenatal Diagnosis
Context:
- Fetal sampling is performed in 6-7% of pregnancies.
- Maternal conditions such as anticoagulating treatment, vaginal bleeding, and fever can complicate fetal sampling.
- Standard fetal sampling procedures may require modification in complex maternal contexts.
Purpose:
- To establish evidence-based guidelines for fetal sampling in pregnancies with challenging maternal circumstances.
- To address the difficulties encountered during fetal sampling due to specific maternal health factors.
- To provide a practical framework for clinicians managing high-risk fetal sampling procedures.
Summary:
- A review of literature and a survey of French multidisciplinary centers for prenatal diagnosis were conducted.
- Guidelines were developed to manage fetal sampling when complicated by maternal conditions.
- The findings aim to standardize and improve the safety of fetal sampling in difficult cases.
Impact:
- Improved management protocols for fetal sampling in high-risk pregnancies.
- Enhanced safety and efficacy of prenatal diagnostic procedures.
- Support for clinicians in making informed decisions during complex fetal sampling scenarios.
Keywords:
AmniocentesisAmniocentèseAnomalie congénitale de l’hémostaseAnticoagulating treatmentChorionic villus samplingDiagnostic prénatalFeverFièvreInfection viraleInherited hemostasis disorderMyomatous uterusMétrorragiesObesityObésitéPrenatal diagnosisPrélèvement de villosités chorialesTraitement anticoagulantUtérus fibromateuxVaginal bleedingViral infection
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