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Updated: May 9, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
[Growth charts and intrauterine growth retardation]
J-B Gouyon1, C Ferdynus, C Quantin
1Centre d'études périnatales de l'Océan Indien, groupe hospitalier Sud Réunion, CHU, BP 350, avenue François-Mitterrand, 97448 Saint-Pierre cedex, France. jean-bernard.gouyon@chu-reunion.fr
Insights
Intrauterine growth restriction (IUGR) means a fetus isn't reaching its growth potential. While growth charts help estimate this, their individual predictive value for fetal and neonatal outcomes is limited.
Area of Science:
- Obstetrics and Gynecology
- Neonatology
- Pediatric Growth and Development
Context:
- Intrauterine growth restriction (IUGR) signifies a fetus failing to achieve its genetic growth potential.
- Growth charts, both fetal and neonatal, are used to approximate individual growth potential.
- Fetal growth charts estimate fetal weight from biometric data, while neonatal charts use birth weight.
Purpose:
- To differentiate between fetal and neonatal growth charts and their respective applications.
- To highlight the differences and limitations of current growth charting methods for assessing intrauterine growth restriction.
- To underscore the clinical and epidemiological significance of IUGR and its associated risks.
Summary:
- Neonatal and fetal growth charts are not interchangeable and have distinct clinical and epidemiological meanings.
- Fetal growth charts assess growth velocity, but individual fetal weight estimation can lack precision.
- Neonatal charts, based on population data, differ significantly from fetal charts, especially for preterm infants often affected by maternal conditions.
Impact:
- Intrauterine growth restriction (IUGR) is a significant risk factor for fetal mortality, neonatal mortality, and both short- and long-term morbidity.
- Despite the risks, the predictive accuracy of current growth charts, customized or not, at an individual level is low.
- Further investigations are necessary to improve the predictive value of growth assessments for individual fetal and neonatal outcomes.
Abstract:
Intrauterine growth restriction indicates that a fetus is unable to achieve its growth potential. The individual growth potential is approximated by customization of growth charts. Neonatal growth charts rely on body weight measures at birth while fetal growth charts rely on body weight estimated from biometric measurements of the fetus. The neonatal and fetal growth charts are not equivalent and have different meanings for epidemiologists and clinicians. Fetal growth charts also assess fetal growth velocity, but individual assessment of fetal weight may be flawed by lack of precision. Neonatal charts are constructed based on data obtained in the whole population or in a subgroup without gestational diseases. The two types of neonatal charts markedly differ at low gestational ages as 30% of preterm infants present intrauterine growth restriction, usually due to maternal diseases. Even if intrauterine growth restriction is a risk factor of fetal mortality, neonatal mortality, and short- and long-term morbidity, the predictive value of the charts (whether or not they are customized) at an individual level is low and may be improved by additional investigations.
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