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Overview of Lipid Metabolism01:24

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Related Experiment Video

Updated: May 9, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Adipocyte and adipogenesis.

Aus Tariq Ali1, Warren E Hochfeld, Renier Myburgh

  • 1Department of Chemical Pathology, Tygerberg Hospital, Cape Town, South Africa. atali@sun.ac.za

European Journal of Cell Biology
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

Adipocytes, key cells in metabolism, store and release energy. Their development, adipogenesis, is crucial for whole-body energy balance and can lead to obesity if dysregulated.

Keywords:
AdipocyteAdipogenesisDeterminationDifferentiation

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Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
08:28

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

Area of Science:

  • Metabolic Science
  • Cell Biology
  • Endocrinology

Background:

  • Adipocytes are central to whole-body metabolism, regulating energy balance through fat storage and mobilization.
  • Beyond energy storage, adipocytes function as an endocrine organ, influencing appetite, insulin sensitivity, and vascular health.
  • Adipogenesis, the development of mature adipocytes from preadipocytes, involves complex molecular pathways and transcription factors like C/EBP and PPAR-γ.

Purpose of the Study:

  • To elucidate the critical role of adipocytes in metabolic homeostasis.
  • To detail the molecular mechanisms and regulatory factors governing adipogenesis.
  • To understand how adipogenesis contributes to adipose tissue expansion and obesity.

Main Methods:

  • Review of molecular pathways involved in adipocyte determination and differentiation.
  • Identification of key transcription factors and signaling molecules regulating adipogenesis.
  • Analysis of factors that stimulate or inhibit adipogenesis.

Main Results:

  • Adipogenesis requires sequential activation of transcription factors, including C/EBP and PPAR-γ.
  • Identified stimulators (e.g., PPAR-γ, IGF-I) and inhibitors (e.g., TGF-β, inflammatory cytokines) of adipogenesis.
  • Adipogenesis contributes to white adipose tissue expansion, potentially leading to obesity.

Conclusions:

  • Adipocytes are crucial endocrine cells regulating systemic metabolism.
  • Understanding adipogenesis pathways is vital for metabolic health and obesity research.
  • Dysregulated adipogenesis can lead to pathological conditions such as obesity.