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Related Experiment Videos

Aging changes of the rhesus monkey optic nerve.

J C Morrison1, L C Cork, G R Dunkelberger

  • 1Oregon Health Sciences University, Portland.

Investigative Ophthalmology & Visual Science
|August 1, 1990
PubMed
Summary

This study found significant variation in optic nerve axon counts among rhesus monkeys. While older animals generally had fewer axons, age-related loss was not statistically significant, with no effect on axon diameter.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Primate Research

Background:

  • The optic nerve's axonal count is crucial for visual function.
  • Understanding age-related changes in the optic nerve is vital for diagnosing and treating vision loss.

Purpose of the Study:

  • To quantify optic nerve axon numbers in juvenile and aged rhesus monkeys.
  • To investigate the relationship between age and optic nerve axon count and diameter.

Main Methods:

  • Automated image analysis was used to count axons in optic nerves from 28 rhesus monkeys.
  • Animal ages ranged from 1.5 to 29 years, correlating to human ages of 4.5 to 87 years.
  • Nerves were fixed immediately post-mortem and processed identically.

Main Results:

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  • The mean axonal number across all specimens was 1,117,859.
  • Significant variation in axon numbers was observed, even within young age groups.
  • A trend of more fibers in younger nerves was noted, but age-related loss (4319 fibers/year, 0.45%) was not statistically significant.
  • Age did not significantly impact mean axonal diameter.

Conclusions:

  • Optic nerve axon counts exhibit substantial individual variability, independent of age.
  • Age-related optic nerve axon loss may occur but was not statistically significant in this cohort.
  • Axon diameter remains consistent across the studied age range.