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Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

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Related Experiment Video

Updated: May 9, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Pseudo-hypertriglyceridaemia or hyperglycerolemia?

T Arrobas-Velilla1, R Mondéjar-García, J A Gómez-Gerique

  • 1Profesora de la Facultad de Medicina de la Universidad Autónoma de Chile, Talca, Chile; Laboratorio de Nutrición y Riesgo Vascular, U.G.C. de Bioquímica Clínica, Hospital Universitario Virgen Macarena, Sevilla, Spain.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

A rare genetic disorder, hyperglycerolemia, can cause falsely high triglyceride levels due to glycerol kinase deficiency. This case highlights a patient with pseudo-hypertriglyceridaemia unresponsive to standard lipid-lowering treatments.

Keywords:
Glicerol quinasaGlycerol kinaseHiperglicerolemiaHyperglycerolemiaPseudo-hipertrigliceridemiaPseudohypertriglyceridaemia

Related Experiment Videos

Last Updated: May 9, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Area of Science:

  • Biochemistry
  • Clinical Genetics
  • Endocrinology

Background:

  • Hyperglycerolemia, a rare genetic disorder from glycerol kinase deficiency, is often undiagnosed.
  • Standard lab tests typically exclude glycerol and glycerol kinase activity analysis.
  • Glycerol can interfere with assays for triglycerides and ethylene glycol.

Observation:

  • A Spanish patient presented with pseudo-hypertriglyceridaemia, showing falsely elevated serum triglycerides.
  • This condition persisted despite 3 years of lipid-lowering therapy.
  • Glycerol kinase deficiency was suspected as the underlying cause.

Findings:

  • The patient's elevated triglycerides were not due to typical hypertriglyceridaemia but glycerol interference.
  • This case underscores the diagnostic challenge of glycerol kinase deficiency.
  • Pseudo-hypertriglyceridaemia can mimic genuine lipid disorders.

Implications:

  • Highlights the need for specific glycerol testing in unexplained hypertriglyceridaemia.
  • Informs clinicians about potential biochemical interferences in lipid testing.
  • Emphasizes the importance of considering rare genetic disorders in persistent metabolic abnormalities.