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Related Experiment Video

Updated: May 9, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Making vaccines "on demand": a potential solution for emerging pathogens and biodefense?

Anne S De Groot¹, Leo Einck, Leonard Moise

¹EpiVax, Inc.; Providence, RI USA; Institute for Immunology and Informatics; University of Rhode Island; Providence, RI USA.

Human Vaccines & Immunotherapeutics

|July 24, 2013

Summary

Rapid vaccine design using computational tools can accelerate responses to novel pathogens and WMD threats. This approach significantly reduces development timelines, enhancing national biodefense capabilities for emerging public health emergencies.

Keywords:

H5N1 H7N9 SARS biothreat coronavirus emerging infectious disease immunoinformatics medical countermeasure vaccine

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Last Updated: May 9, 2026

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Area of Science:

Biodefense and Public Health
Vaccinology
Computational Biology

Background:

The US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has advanced preparedness, but structural delays hinder rapid response to novel pathogens.
Emerging threats like avian influenza (H7N9, H5N1) and novel coronaviruses necessitate faster countermeasures.
Conventional vaccine development timelines are insufficient for prompt public health responses to biothreats.

Purpose of the Study:

To propose an alternative approach for rapid vaccine development against novel pathogens and WMD agents.
To highlight the potential of computational vaccine design and rapid production technologies.
To demonstrate a significantly reduced timeline for vaccine design and readiness.

Main Methods:

Utilizing computational vaccine design tools to engineer "string-of-epitope" vaccines.
Leveraging rapid production technologies for accelerated manufacturing.
Focusing on designing vaccines from genome to gene sequence for DNA plasmid insertion.

Main Results:

Computational design process from genome to gene sequence can be completed in under 24 hours.
Proposed rapid vaccine development offers a potential 60-day start-to-finish timeline.
This represents a significant acceleration compared to current standard vaccine development processes.

Conclusions:

Innovative vaccine design and production methods are crucial for effective biodefense.
Computational tools and rapid technologies can drastically shorten response times to emerging infectious disease threats.
Accelerated vaccine development is essential for national biodefense rapid response capabilities.