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Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Updated: May 9, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Wound coverage technologies in burn care: novel techniques.

Marc G Jeschke¹, Celeste C Finnerty, Shahriar Shahrokhi

¹From the *University of Toronto; †Department of Surgery, Division of Plastic Surgery, ‡Department of Immunology, and §Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre; ‖Sunnybrook Research Institute; ¶Department of Surgery, Sealy Center for Molecular Medicine, and the Institute for Translational Science, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston; and #Department of Plastic and Reconstructive Surgery, Hannover Medical School, Germany.

Journal of Burn Care & Research : Official Publication of the American Burn Association

|July 24, 2013

Summary

Advanced burn wound care is improving patient outcomes. New therapies using tissue engineering, stem cells, and surgical techniques promise to revolutionize treatment for severe burns and reduce complications.

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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Area of Science:

Regenerative Medicine
Wound Healing Research
Biotechnology

Background:

Burn wound care advancements have significantly reduced patient mortality and morbidity.
New therapeutic strategies are crucial to minimize complications such as infection, graft rejection, and hypertrophic scarring.

Purpose of the Study:

To review recent promising developments in investigational burn wound care.
To highlight novel approaches in enhancing wound repair and regeneration.

Main Methods:

Review of current literature on tissue engineering in wound healing.
Analysis of studies involving exogenous proteins, gene therapy, and stem cell applications.
Examination of advancements in surgical techniques, including facial transplantation.

Main Results:

Tissue-engineering, exogenous proteins, gene therapy, and stem cells show potential for enhanced wound healing.
Surgical refinements have led to protocols for full facial transplantation.
These innovations are poised to transform burn care over the next decade.

Conclusions:

Emerging technologies in regenerative medicine and surgical techniques offer significant promise for improving outcomes in severe burn patients.
Continued research and development in these areas are expected to revolutionize burn wound management and reduce long-term complications.