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Updated: May 9, 2026
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Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining
Published on: May 9, 2025
Primary hepatic Ewing's sarcoma with cytogenetic confirmation
P F McGrann1, I J Pooleman, C H Wilson
1Department of Hepatopancreaticobiliary Surgery, The Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne, UK, NE7 7DN.
Summary
This case report details a rare instance of extraskeletal Ewing's sarcoma presenting as a resectable liver mass in a 29-year-old male. Surgical resection is highlighted as the primary treatment for optimal outcomes.
Area of Science:
- Oncology
- Surgical Pathology
- Genetics
Background:
- Extraskeletal Ewing's sarcoma (EES) is a rare malignant tumor.
- EES typically arises in soft tissues, with hepatic presentation being exceptionally uncommon.
- No prior reports describe EES presenting as a resectable liver mass.
Observation:
- A 29-year-old male presented with a large, symptomatic liver mass.
- The mass was located in the right lobe of the liver.
- The patient underwent surgical resection of the liver mass.
Findings:
- Histopathological examination revealed features characteristic of Ewing's sarcoma.
- The EWSR1-Fli1 fusion protein, a hallmark of Ewing's sarcoma, was detected.
- This confirmed the diagnosis of extraskeletal Ewing's sarcoma of the liver.
Implications:
- Complete surgical resection is crucial for favorable long-term prognosis in hepatic EES.
- Combined surgical and chemotherapeutic management offers cure rates between 30-60%.
- This case expands the known clinical spectrum of extraskeletal Ewing's sarcoma.
