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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
Anita Gianella1, Aneta J Mieszawska, Freek J M Hoeben
1Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. willem.mulder@mssm.edu.
Chemical Communications (Cambridge, England)
|July 24, 2013
Abstract:
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
