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[Phyllodes tumor of the breast: clinicopathologic analysis of 22 cases]
Magalie Velázquez-Dohorn1, Armando Gamboa-Domínguez, Heriberto Medina-Franco
1Facultad de Medicina, Benemérita Universidad Autónoma de Puebla.
Introduction:
Phyllodes tumors of the breast are uncommon fibroepithelial neoplasms that have potential for recurrence. They are classified as benign, borderline, and malignant, based on a constellation of histologic characteristics that includes the degree of stromal hypercellularity, cytologic atypia and mitotic activity.
Objective:
To analyze the clinical and pathological features of 22 women treated at a referral center in Mexico City.
Material And Methods:
We performed a retrospective analysis of women with phyllodes tumors of the breast treated at our institution between 1998 and 2011. Age, tumor size, surgical method, stromal cellular atypia, mitotic activity, stromal overgrowth, histological classification and surgical margin status were analyzed to determine their possible association with tumor recurrence.
Results:
Mean patient age at presentation was 42 years. Ten of them (43.5%) had late menarche. Six patients (27.27%) used hormones. Twenty patients (91%) had tumor detected by self-examination. Mean size of the lesion was 7.4 cm. Most lesions were located in the upper outer quadrant (77.3%) and in the left breast (59.1%). Fourteen patients (63.6%) were treated with conservative surgery. Three patients (13.6%) presented local recurrence, two as benign tumors and one patient with two recurrences, first as benign tumor thereafter as malignant phyllodes tumor at 72 and 108 months respectively.
Conclusions:
. In our study, surgical positive margin status is the main prognostic factor for recurrence.
