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Updated: May 9, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Influence of PRF in the healing of bone and gingival tissues. Clinical and histological evaluations
1Tecnologica Research Institute, Biomedical Section, Crotone, Italy.
Introduction:
The healing of bone tissues around dental implants is based primarily on a correct osseointegration.
Background:
Typically, implants stability and peri-implant tissues health are anticipated to decrease during the early weeks of healing; this is followed by an increase in stability.
Aim:
The aim of the present study is to assess a predictable protocol in order to increase the peri-implant tissues maintenance around post-extractive dental implants, thanks to the use of Platelet-Rich Fibrin (PRF) membrane.
Materials And Methods:
This is a retrospective observational study of 127 tapered dental implants placed in the immediate post-extraction sites of maxillary bone of 59 patients. Atraumatic dental extraction and flapless implant surgery was performed in all reported cases. The cortical bone position relative to the implant reference point was evaluated at implant placement and 10 to 24 months following implantology. The gap between bone tissue and the implant surface was measured up to a maximum of 3 mm. After placing implants we have filled the surgical site with a PRF gel, so as to fill the gap between bone tissue and the implant surface, and then we have covered the surgical site with a PRF membrane, so as to coat the gap between the alveolar crest and the implant.
Results:
In all cases, we observed the complete covering of the dental implants, with newly formed soft tissue of variable thickness between 1 and 3 mm. Cortical bone adaptation from the time of implant placement up to 30 months following prosthetic restoration ranged from 0.4 mm to 1.7 mm.
Conclusions:
Our study showed a series of successful rehabilitations, with post-extraction implantology technique, in 99.8 percent of cases, despite the success rates in the medium and long-term post-extraction implantology reported in the literature range between 92.7 percent and 98.0 percent. Long-term maintenance of crestal bone and the rapid healing of soft tissue dimension with maintenance of peri-implant papilla were observed as outcomes after post-extractive implants insertion.