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Risk of a recurrent cardiovascular event in individuals with type 2 diabetes or intermediate hyperglycemia: the Hoorn

Amber A W A van der Heijden1, Esther Van't Riet, Sandra D M Bot

  • 1Corresponding author: Amber A.W.A. van der Heijden, a.vanderheijden@vumc.nl.

Diabetes Care
|July 24, 2013
PubMed

Insights

Individuals with type 2 diabetes face a higher risk of recurrent cardiovascular events. Early identification of at-risk patients using pre-event profiles is crucial for managing cardiovascular disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) poses a significant health burden.
  • Understanding risk factors for recurrent CVD events is critical for patient management.
  • Glucose metabolism plays a role in cardiovascular health.

Purpose of the Study:

  • To determine the risk of recurrent cardiovascular events in a population-based cohort.
  • To identify predictors of recurrent cardiovascular events.
  • To compare event risk across different glucose metabolism statuses.

Main Methods:

  • Prospective follow-up of 336 individuals with a first cardiovascular event (Hoorn Study).
  • Calculation of absolute risk for recurrent events based on glucose metabolism (normal, intermediate hyperglycemia, type 2 diabetes).
  • Cox regression models used to identify predictors of recurrent events.

Main Results:

  • 44% of participants experienced a recurrent vascular event during a median 4.1-year follow-up.
  • Recurrent event rates per 100 person-years were 7.2 (normal glucose), 9.8 (intermediate hyperglycemia), and 12.5 (type 2 diabetes).
  • Predictors included higher age, male sex, waist circumference, systolic blood pressure, HbA1c, and family history of myocardial infarction.

Conclusions:

  • Type 2 diabetes is associated with an increased risk of recurrent vascular events compared to normal glucose metabolism.
  • Intermediate hyperglycemia did not show a statistically significant increased risk.
  • Patient risk profiles established before the first event can identify individuals at higher risk for recurrence.
Abstract

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