Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory bacterial epidemiology at three primary ciliary dyskinesia clinical centers.

Journal of the Pediatric Infectious Diseases Society·2026
Same author

Treatment patterns and adherence to lipid-lowering therapy, LDL-C control, clinical outcomes, and healthcare resource utilization in treated patients with hypercholesterolemia at high cardiovascular risk in Israel: a retrospective database study.

Frontiers in cardiovascular medicine·2026
Same author

RadD from <i>Fusobacterium nucleatum</i> engages NKp46 to promote antitumor cytotoxicity.

eLife·2026
Same author

The Genetics of Primary Ciliary Dyskinesia - Advances and Limitations.

Pediatric pulmonology·2026
Same author

The Diagnosis of Primary Ciliary Dyskinesia: Putting The European Respiratory/American Thoracic Guideline Into Practice.

Pediatric pulmonology·2026
Same author

Editorial Expression of Concern: Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.

Scientific reports·2026

Related Experiment Video

Updated: May 9, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

NKp46 regulates allergic responses.

Hormas Ghadially1, Amjad Horani, Ariella Glasner

  • 1The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

European Journal of Immunology
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cells regulate T-cell allergic responses via the NKp46 receptor. This finding reveals a new role for NK cells in controlling hypersensitivity and altering immune cell cytokine profiles.

Keywords:
AllergyDendritic cellsNK cellsNKp46Ncr1

More Related Videos

A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: May 9, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

A BW Reporter System for Studying Receptor-Ligand Interactions
06:05

A BW Reporter System for Studying Receptor-Ligand Interactions

Published on: January 7, 2019

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Natural killer (NK) cells are crucial cytotoxic lymphocytes involved in innate immunity.
  • NK cell activity is regulated by a balance of activating and inhibitory receptors.
  • Beyond cytotoxicity, NK cells have diverse functions, including roles in pregnancy and immune regulation.

Purpose of the Study:

  • To investigate the role of NK cells in T-cell mediated allergic responses.
  • To determine if the NK-cell specific receptor NKp46 (Ncr1) is involved in regulating allergic reactions.
  • To elucidate the mechanisms by which NK cells influence T-cell responses in allergy.

Main Methods:

  • Utilized genetically modified mice with Ncr1 gene replaced by green fluorescent protein (Ncr1-GFP mice).
  • Assessed delayed-type hypersensitivity and airway hypersensitivity responses in Ncr1-GFP mice.
  • Analyzed T-cell stimulation and cytokine profiles to understand the underlying mechanisms.

Main Results:

  • Ncr1-GFP mice exhibited reduced delayed-type hypersensitivity and airway hypersensitivity.
  • The observed reduction in airway hypersensitivity was linked to altered T-cell stimulation.
  • A distinct cytokine profile was identified in T cells, indicating NK cell-mediated immunomodulation.

Conclusions:

  • NK cells, specifically through the NKp46 receptor, play a significant role in regulating T-cell mediated allergic responses.
  • NK cells can modulate T-cell activation and cytokine production, impacting hypersensitivity.
  • This study uncovers a novel function of NK cells in the context of allergic diseases.