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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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Related Experiment Video

Updated: May 9, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

Malignant eccrine hidradenoma.

David J Cauthon1, Tucker Worthen, Lewis Freed

  • 1Arizona School of Podiatric Medicine, Midwestern University, Glendale, AZ 85308, USA. david.cauthon@gmail.com

Journal of the American Podiatric Medical Association
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

Malignant hidradenomas, rare sweat gland tumors, are often misdiagnosed. This case highlights successful treatment of a heel hidradenoma using wide excision and vacuum-assisted closure.

Related Experiment Videos

Last Updated: May 9, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Hidradenomas are adenomatous tumors originating from sweat glands, typically benign but potentially fatal when malignant.
  • Malignant hidradenomas present diagnostic challenges due to their rarity and clinical ambiguity, often mistaken for other soft-tissue masses.
  • Current treatment options for malignant hidradenomas are limited, with radiation and chemotherapy showing minimal benefit.

Observation:

  • A case of malignant hidradenoma presenting on the medial heel of a patient is described.
  • Initial diagnosis was challenging due to the tumor's location and presentation.

Findings:

  • Wide aggressive excision and lymphadenectomy are the recommended treatments for malignant hidradenomas.
  • This patient's malignant hidradenoma was successfully treated with wide excision.
  • Delayed closure using vacuum-assisted closure was employed effectively after tumor removal.

Implications:

  • This case underscores the importance of considering hidradenoma in the differential diagnosis of unusual skin tumors.
  • Effective management of malignant hidradenoma relies on surgical intervention, potentially including advanced wound closure techniques.
  • Further research into optimal treatment strategies for malignant hidradenomas is warranted.