Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage.

Neurocritical care·2016
Same author

To Be-et, or Not to Be-et, That is the Question: The Role(s) of Nitrate and Nitrite in Health and Illness.

Reviews on recent clinical trials·2016
Same author

Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.

Neurological research·2016
Same author

Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.

PloS one·2015
Same author

Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.

Journal of neurosurgery·2015
Same author

Early events after aneurysmal subarachnoid hemorrhage.

Acta neurochirurgica. Supplement·2014

Related Experiment Video

Updated: May 9, 2026

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

Aneurysmal subarachnoid hemorrhage models: do they need a fix?

Fatima A Sehba1, Ryszard M Pluta

  • 1Departments of Neurosurgery and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

Stroke Research and Treatment
|July 24, 2013
PubMed
Summary

Developing effective treatments for brain injury after aneurysmal subarachnoid hemorrhage (aSAH) requires better animal models. This review proposes a modified aSAH model, informed by transient cerebral ischemia (TGI) research, to advance treatment development.

More Related Videos

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Related Experiment Videos

Last Updated: May 9, 2026

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Area of Science:

  • Neuroscience
  • Translational Medicine
  • Medical Research

Background:

  • Acute stroke treatments, like tissue plasminogen activator for transient cerebral ischemia (TGI), highlight the importance of accurate animal models.
  • Despite extensive research, effective treatments for brain injury following aneurysmal subarachnoid hemorrhage (aSAH) remain elusive, potentially due to inadequate disease models.

Purpose of the Study:

  • To explore the similarities and differences between TGI and aSAH injury mechanisms.
  • To evaluate existing TGI and aSAH animal models.
  • To propose a modified aSAH model that better replicates the disease and aids in developing treatments.

Main Methods:

  • Comparative analysis of TGI and aSAH pathophysiology.
  • Review of current animal models for TGI and aSAH.
  • Development and description of a modified aSAH model.

Main Results:

  • TGI and aSAH share injury mechanisms, but differ in key aspects.
  • Existing aSAH models have limitations in fully mimicking the human condition.
  • The proposed modified aSAH model demonstrates improved disease mimicry.

Conclusions:

  • Improving aSAH modeling is crucial for advancing therapeutic strategies.
  • The modified aSAH model offers a promising platform for studying aSAH-induced brain injury.
  • This enhanced model could accelerate the development of treatments for aSAH and its complications.