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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Osteoclasts in Bone Remodeling

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Related Experiment Video

Updated: May 9, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Orthopaedic perspective on bone metastasis.

Alan P Molloy1, Gary C O'Toole

  • 1Alan P Molloy, Gary C O'Toole, Department of Orthopaedic Oncology, St Vincents Hospital, Dublin 4, Ireland.

World Journal of Orthopedics
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

Cancer bone metastases are increasing, posing orthopaedic challenges. Individualized treatment considering lesion type and patient outcomes is crucial for better survival.

Keywords:
Bone metastasesDiagnosisPathophysiologySurgical treatment, Medical treatment

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Related Experiment Videos

Last Updated: May 9, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

Area of Science:

  • Oncology
  • Orthopaedic Surgery
  • Bone Metastasis Research

Background:

  • Global cancer incidence is rising, leading to increased patient survival.
  • This results in a growing number of patients with bone metastases, presenting significant orthopaedic challenges.
  • Bone metastases can cause pain, hypercalcemia, and pathological fractures.

Purpose of the Study:

  • To emphasize the need for individualized treatment strategies for bone metastases.
  • To highlight the importance of considering lesion characteristics and patient outcomes in treatment planning.
  • To advocate for a multidisciplinary approach in managing bone metastases.

Main Methods:

  • Review of current understanding of bone metastasis dissemination.
  • Discussion of existing surgical and non-operative treatment options.
  • Emphasis on patient-specific care and multidisciplinary collaboration.

Main Results:

  • Bone metastasis management requires a personalized approach.
  • Understanding tumor dissemination pathways is key to developing new treatments.
  • Multidisciplinary care improves patient outcomes.

Conclusions:

  • Orthopaedic surgeons play a vital role in the multidisciplinary team for bone metastasis treatment.
  • Individualized treatment plans are essential for managing bone metastases effectively.
  • Further research into metastasis pathways can lead to improved medical therapies.