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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Central nervous system venulitis presenting as migraine.

Serena L Orr¹, Marlise P Dos Santos, Roman Jurencak

¹Children's Hospital of Eastern Ontario, ON, Canada; University of Ottawa, ON, Canada.

|July 25, 2013

Summary

This case study highlights pediatric central nervous system (CNS) venulitis, a rare condition presenting as severe migraines and hemiplegia. Early diagnosis and treatment with immunosuppressants led to significant clinical improvement in a young patient.

Keywords:

central nervous system vasculitis central nervous system venulitis headache migraine pediatric primary angiitis of the central nervous system

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Published on: April 28, 2019

Area of Science:

Neurology
Pediatrics
Immunology

Background:

Primary angiitis of the CNS is a rare cause of pediatric morbidity, typically affecting arteries.
Isolated central nervous system (CNS) venulitis in pediatric patients is exceptionally rare, with limited documented cases.

Observation:

A 17-year-old female presented with worsening migraines and right-sided hemiplegia.
Brain MRI revealed multiple rim-enhancing lesions suggestive of calcifications in the deep white matter.
Brain biopsy confirmed an inflammatory process affecting small veins and venules.

Findings:

The patient's symptoms, including migraines and hemiplegia, were attributed to pediatric CNS venulitis.
Diagnostic workups for infectious, hematologic, and rheumatologic causes were negative.
Histopathological examination of brain biopsy revealed venulitis.

Implications:

This case expands the understanding of CNS venulitis presentation in pediatric populations.
Prompt immunosuppressive therapy, including steroids and cyclophosphamide, can effectively manage pediatric CNS venulitis.
Migraine presentation should prompt consideration of CNS venulitis in pediatric differential diagnoses.