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Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride01:26

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The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...
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Related Experiment Video

Updated: May 9, 2026

In Situ Synthesis of Gold Nanoparticles without Aggregation in the Interlayer Space of Layered Titanate Transparent Films
07:08

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Published on: January 17, 2017

Structure confirmation of altertenuol.

Robert Thomas1, Gregor Nemecek, Joachim Podlech

  • 1a 27 Abbotswood , Guildford Surrey GU1 1UY , UK.

Natural Product Research
|July 25, 2013
PubMed
Summary

Authentic altertenuol and synthetically produced altenuisol were compared. Nuclear magnetic resonance (NMR) spectral analysis confirmed that altertenuol and altenuisol are the same chemical compound.

Area of Science:

  • Natural Product Chemistry
  • Organic Synthesis
  • Spectroscopy

Background:

  • Altertenuol is a natural product with potential biological activities.
  • Altenuisol has been synthesized, but its identity relative to altertenuol was unclear.

Purpose of the Study:

  • To determine if altertenuol and altenuisol are identical compounds.
  • To confirm the structure of synthesized altenuisol.

Main Methods:

  • Total synthesis of altenuisol.
  • Comparison of the synthetic altenuisol with an authentic sample of altertenuol.
  • Analysis of nuclear magnetic resonance (NMR) spectra.

Main Results:

  • The nuclear magnetic resonance spectra of authentic altertenuol and synthetic altenuisol were identical.

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  • This indicates that altertenuol and altenuisol are the same chemical entity.
  • Conclusions:

    • Altertenuol and altenuisol are unequivocally identified as the same compound.
    • The total synthesis successfully produced altertenuol, now identified as altenuisol.