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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association between TLR4 polymorphism and periodontitis susceptibility: a meta-analysis
Jingjing Zheng1, Ling Gao, Tiezhou Hou
1Department of Endodontics, Stomatological Hospital, College of Medicine, Xi’an Jiaotong University, No. 98 Xiwu Road, Xincheng District, Xi’an, Shaanxi, 710004, P R China.
Critical Reviews in Eukaryotic Gene Expression
|July 25, 2013
Summary
This study found no significant link between common Toll-like receptor 4 (TLR4) gene variations and periodontitis risk. Further research is needed to explore genetic interactions in TLR4 signaling and periodontal disease susceptibility.
Area of Science:
- Genetics
- Immunology
- Oral Health
Background:
- Periodontal disease is a common inflammatory condition affecting the gums.
- Toll-like receptor 4 (TLR4) plays a role in immune responses and has been linked to periodontal disease.
- The specific association of TLR4 Asp299Gly and Thr399Ile polymorphisms with periodontitis risk requires clarification.
Purpose of the Study:
- To investigate the association between TLR4 Asp299Gly and Thr399Ile polymorphisms and the risk of developing periodontal disease.
- To analyze the impact of these polymorphisms on chronic and aggressive periodontitis.
- To evaluate the influence of ethnicity and periodontitis type on this association.
Main Methods:
- A comprehensive meta-analysis of existing electronic database studies.
- Evaluation of the association using odds ratios (OR) and 95% confidence intervals (CI).
- Stratified analyses based on periodontitis type (chronic, aggressive), ethnicity, and genetic models (recessive).
Main Results:
- The meta-analysis indicated no significant association between TLR4 Asp299Gly and Thr399Ile polymorphisms and overall periodontitis risk.
- Stratified analyses by periodontitis type and ethnicity did not reveal any significant increased risk.
- A significant increased risk for periodontitis was observed in recessive models for the Asp299Gly polymorphism.
Conclusions:
- Common TLR4 polymorphisms (Asp299Gly and Thr399Ile) are not generally associated with periodontitis susceptibility.
- Genetic networks and pathway interactions within TLR4 signaling may influence periodontitis risk and warrant further investigation.
- The role of specific genetic models, like the recessive model for Asp299Gly, requires additional research to understand its impact on periodontitis.
