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Leptin and plasminogen activator inhibitor-1 levels in children on chronic dialysis

Pinar Isik Agras1, Esra Baskin, Nurcan Cengiz

  • 1Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. pinaris2001@yahoo.com

Renal Failure
|July 25, 2013
PubMed

Insights

Children on hemodialysis (HD) have higher serum leptin and PAI-1 levels compared to healthy children. These elevated levels are significantly correlated in both hemodialysis and peritoneal dialysis patients.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Chronic kidney disease (CKD) in children often requires renal replacement therapy.
  • Hemodialysis (HD) and peritoneal dialysis (PD) are common treatment modalities.
  • Leptin and Plasminogen Activator Inhibitor-1 (PAI-1) are implicated in metabolic and cardiovascular complications.

Purpose of the Study:

  • To compare serum leptin and PAI-1 levels in pediatric patients undergoing HD versus PD.
  • To evaluate the relationship between leptin and PAI-1 in these pediatric patient groups.

Main Methods:

  • Cross-sectional study including 36 HD patients, 19 PD patients, and 15 healthy controls.
  • Measurement of serum leptin and PAI-1 levels.
  • Statistical analysis controlling for BMI and sex.

Main Results:

  • Serum leptin levels were significantly higher in the HD group compared to controls, with no significant difference between PD and control groups.
  • PAI-1 levels were significantly elevated in the HD group versus controls; PD and control groups showed no significant difference.
  • Leptin and PAI-1 levels were significantly correlated in both HD and PD groups, independent of BMI.

Conclusions:

  • Pediatric patients on HD exhibit higher serum leptin and PAI-1 levels than healthy children.
  • A significant correlation exists between leptin and PAI-1 levels in pediatric HD and PD patients.
  • Further research is needed to determine the impact of these elevated markers on cardiovascular complications.
Abstract

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