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Genome-enabled methods for predicting litter size in pigs: a comparison.

L Tusell1, P Pérez-Rodríguez, S Forni

  • 11 Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Animal : an International Journal of Animal Bioscience
|July 25, 2013
PubMed
Summary
This summary is machine-generated.

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Genomic models improved litter size prediction in swine compared to traditional methods. Bayesian regularized neural networks showed the highest predictive ability, especially in crossbred pigs.

Area of Science:

  • Animal Genetics
  • Quantitative Genetics
  • Swine Breeding

Background:

  • Accurate prediction of litter size is crucial for efficient swine production.
  • Genomic selection offers potential for improving predictive accuracy over pedigree-based methods.

Purpose of the Study:

  • To investigate the predictive ability of various genetic models for litter size in swine.
  • To compare the performance of different genomic and pedigree-based models across purebred and crossbred lines.

Main Methods:

  • Evaluated pedigree-based mixed-effects model (PED), Bayesian ridge regression (BRR), Bayesian LASSO (BL), genomic BLUP (GBLUP), reproducing kernel Hilbert spaces regression (RKHS), Bayesian regularized neural networks (BRNN), and radial basis function neural networks (RBFNN).
  • Utilized 60K SNP data from 2598, 1604, and 1897 genotyped sows across two purebred and one crossbred line.

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  • Assessed predictive ability using 10-fold cross-validation and average correlation (r) between observed and predicted phenotypes.
  • Main Results:

    • Genome-based models generally outperformed the pedigree-based model (PED).
    • Non-parametric models (RKHS, BRNN, RBFNN) showed predictive abilities ranging from 0.15 to 0.23, similar to parametric models.
    • Bayesian regularized neural networks (BRNN) achieved the highest prediction accuracy (r = 0.31) in crossbreds using the genomic relationship matrix (G).
    • Predictive ability was higher in crossbreds (0.26) than in purebreds (0.15–0.22), potentially due to family structure differences.

    Conclusions:

    • Genomic information significantly enhances the prediction of litter size in swine.
    • Model choice and population structure (purebred vs. crossbred) influence predictive performance.
    • BRNN demonstrates strong potential for genomic prediction of litter size, particularly in crossbred populations.