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Related Experiment Video

Updated: May 9, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Mesenchymal stem cell transformation and sarcoma genesis.

Wei Xiao¹, Alexander B Mohseny, Pancras C W Hogendoorn

¹Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333ZA, the Netherlands. A.M.Cleton-Jansen@lumc.nl.

Clinical Sarcoma Research

|July 25, 2013

Summary

Mesenchymal stem cells (MSCs) can transform and develop into sarcomas, offering a model for studying cancer development. Understanding MSC transformation is key to developing targeted sarcoma therapies.

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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Area of Science:

Oncology
Stem Cell Biology
Molecular Biology

Background:

Mesenchymal stem cells (MSCs) are implicated as a potential cell of origin for various sarcomas.
Both spontaneous and induced transformation of MSCs have been observed, with implications for sarcomagenesis.
Transformed MSCs can develop into pleomorphic sarcomas upon transplantation, supporting their role in sarcoma development.

Purpose of the Study:

To investigate the role of Mesenchymal stem cells (MSCs) in sarcomagenesis.
To explore the mechanisms underlying MSC transformation and sarcoma development.
To compare transformed MSCs with sarcoma cells to understand their relationship.

Main Methods:

Review and synthesis of existing literature on MSC transformation and sarcomagenesis.
Analysis of expression profiles and differentiation capacities of MSCs and sarcoma cells.
Investigation of implicated molecular pathways (P53, Retinoblastoma, PI3K-AKT, MAPK) in MSC transformation.

Main Results:

Transformed MSCs from both mouse and human origins can form pleomorphic sarcomas in vivo.
Expression profiles and differentiation capacities support an MSC origin for certain sarcomas.
Specific molecular pathways, including P53, Retinoblastoma, PI3K-AKT, and MAPK, are implicated in MSC transformation.

Conclusions:

MSCs serve as a valuable model for studying sarcomagenesis, particularly for non-translocation-induced sarcomas.
Understanding the molecular mechanisms of MSC transformation and sarcoma type determination is crucial for developing targeted therapies.
Further research is needed to fully elucidate the complexities of MSC-derived sarcomas and guide therapeutic strategies.