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Arsenic trioxide induced endoplasmic reticulum stress in laryngeal squamous cell line Hep-2 cells
Xinxin Yang1, Liangxiang An2, Xiaoyu Li3
1Jining Medical University, Jining, Shandong Province, PR China.
Abstract:
Arsenic trioxide (As2O3) has been used in the treatment of acute promyelocytic leukemia (APL) and many malignant solid tumors. Recently, endoplasmic reticulum (ER) stress plays an important role in As2O3-treated laryngeal squamous cell line Hep-2 cells. In the present work, the expression of ER stress-related proteins was investigated in As2O3-treated Hep-2 cells. The results showed that As2O3 increased the expression of GRP78, CHOP, phosphorylated eIF2α and ATF4, all of which are the molecule of ER stress. Therefore, As2O3 induced ER stress in Hep-2 cells.
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