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Urinary adrenomedullin level in children with acute pyelonephritis before and after treatment

Mostafa Sharifian1, Rana Esmaeli Zand, Mitra Ahmadi

  • 1Division of Pediatric Nephrology, Pediatric Nephrology Research Center, Pediatric Infectious Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. sharifian.dorche@gmail.com

Iranian Journal of Kidney Diseases
|July 25, 2013
PubMed

Insights

Urinary Adrenomedullin (AM) levels are elevated in children with acute pyelonephritis and significantly decrease after treatment, indicating its role in urinary tract infections.

Area of Science:

  • Nephrology
  • Pediatrics
  • Biochemistry

Background:

  • Adrenomedullin (AM) is a peptide involved in vasodilation via nitric oxide synthesis.
  • Inflammatory processes stimulate AM production in various cells, including those in the urinary system.
  • Elevated urinary AM concentrations are observed during urinary system inflammation.

Purpose of the Study:

  • To measure urinary AM levels in children diagnosed with acute pyelonephritis.
  • To compare urinary AM levels before and after treatment in these children.
  • To compare urinary AM levels with those in healthy children.

Main Methods:

  • A case-control study involving 31 children with pyelonephritis and 30 healthy children.
  • Urinary AM was quantified using high-performance liquid chromatography.
  • Urinary creatinine was measured to determine the AM-creatinine ratio.

Main Results:

  • Urinary AM-creatinine ratios were significantly higher in children with pyelonephritis (61.3 pg/mg) compared to controls (4.26 pg/mg).
  • Following pyelonephritis treatment, the urinary AM-creatinine ratio decreased significantly (13.1 pg/mg).
  • Higher urinary AM levels correlated with elevated C-reactive protein levels.

Conclusions:

  • Urinary AM levels are elevated during acute pyelonephritis in children.
  • Treatment of pyelonephritis leads to a significant reduction in urinary AM levels.
  • Urinary AM serves as a potential biomarker for pyelonephritis.
Abstract

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