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Assessing the Secretory Capacity of Pancreatic Acinar Cells
09:52

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Published on: August 28, 2014

The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology

Peter Hegyi1, Ole H Petersen

  • 1First Department of Medicine, University of Szeged, Koranyi fsr. 8, SZEGED, H6720, Hungary, hegyi.peter@med.u-szeged.hu.

Reviews of Physiology, Biochemistry and Pharmacology
|July 25, 2013
PubMed

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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