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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

PAP/HIP protein is an obesogenic factor.

Veronique Secq¹, Cecilia Mallmann, Meritxell Gironella

¹Centre de Recherche en Carcérologie de Marseille (CRCM), INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

Journal of Cellular Physiology

|July 25, 2013

Summary

The acute phase protein PAP/HIP promotes obesity by stimulating fat tissue development. PAP/HIP levels are higher in obese patients, suggesting its role in metabolic disease.

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Area of Science:

Biochemistry
Metabolic Research
Obesity Studies

Background:

The acute phase protein PAP/HIP's role in obesity is largely unknown.
Obesity is a complex metabolic disorder with significant health implications.

Purpose of the Study:

To investigate the obesogenic role of PAP/HIP.
To explore PAP/HIP's involvement in fat tissue development and its potential as a therapeutic target.

Main Methods:

Transgenic and knockout mouse models (TgPAP/HIP and PAP/HIP-deficient mice).
In vitro studies using 3T3-L1 preadipocytes.
Analysis of blood markers (glucose, leptin, LDL, triglycerides, HDL).
Investigation of signaling pathways (MEK inhibitor U0126, AG490).
Human patient sample analysis (obese vs. non-obese controls).

Main Results:

TgPAP/HIP mice developed spontaneous obesity with altered blood lipid profiles.
PAP/HIP-deficient mice were leaner.
PAP/HIP expression was induced in the intestine by olive oil gavage.
Recombinant PAP/HIP accelerated preadipocyte proliferation in vitro.
PAP/HIP-induced adipocyte growth was sensitive to MEK inhibition.
Obese patients exhibited higher blood PAP/HIP levels.

Conclusions:

PAP/HIP acts as an obesogenic factor, promoting fat tissue development.
The intestine is a source of PAP/HIP, induced by food intake.
PAP/HIP signaling pathways are involved in adipogenesis.
PAP/HIP represents a potential therapeutic target for obesity.