In vivo effect of molybdenum on benzo(a)pyrene metabolism in liver and lung rat microsomes
1INSERM U 133, Faculté de Médecine, Toulouse, France.
Abstract:
Lung and liver microsomal fractions of rats treated by 40 or 80 mg/kg/day of ammonium heptamolybdate for a period of 8 weeks showed a decrease in the different B(a)P metabolites assessed by high-performance liquid chromatography analysis. When the rats were induced by 3-methylcholanthrene 48 hours before the sacrifice, only the decrease in lung microsomal B(a)P metabolites formation persisted. It is suggested that, by inhibiting the cytochrome P450-dependent monooxygenase activity, Mo could have an influence on the incidence of B(a)P-induced cancer in lung which constituted the target organ for polycyclic aromatic hydrocarbon.
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