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Updated: May 9, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Interactions between alcohol and the HIV entry inhibitor Maraviroc
Valerie A Gruber1, Petrie M Rainey, Paula J Lum
1Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Alcohol consumption does not affect maraviroc pharmacokinetics in HIV patients. Maraviroc treatment can continue even if alcohol is consumed, preventing drug resistance.
Area of Science:
- Pharmacology
- Infectious Diseases
- HIV/AIDS Research
Background:
- Alcohol use is prevalent in people with HIV.
- Concerns exist regarding alcohol-drug interactions and medication adherence.
- Maraviroc is an HIV entry inhibitor for drug-sensitive and resistant strains.
Purpose of the Study:
- To investigate the impact of alcohol on maraviroc pharmacokinetics.
- To assess the effect of maraviroc on alcohol pharmacokinetics.
Main Methods:
- Ten healthy adults participated in the study.
- Alcohol (1 g/kg) and placebo pharmacokinetics were measured.
- Measurements were taken before and after 7 days of maraviroc administration.
Main Results:
- Alcohol concentrations showed a 12% increase after maraviroc administration.
- Maraviroc pharmacokinetics remained unaffected by alcohol consumption.
Conclusions:
- Maraviroc treatment does not need to be interrupted when alcohol is consumed.
- This finding supports continued adherence to HIV treatment.
- Minimizing interruptions in maraviroc therapy can help prevent drug resistance.
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