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Updated: May 9, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Interactions between alcohol and the HIV entry inhibitor Maraviroc
Valerie A Gruber1, Petrie M Rainey, Paula J Lum
1Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Background:
Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations. Maraviroc is an HIV entry inhibitor approved for treatment of both drug-sensitive and drug-resistant HIV strains. The present study evaluated the effects of alcohol on maraviroc pharmacokinetics and the effects of maraviroc on alcohol pharmacokinetics.
Methods:
Ten healthy adults completed alcohol (1 g/kg) and placebo alcohol pharmacokinetics sessions before and after 7 days of maraviroc administration.
Results:
Alcohol concentrations increased 12% following maraviroc. Maraviroc pharmacokinetics were unaffected by alcohol.
Conclusions:
Maraviroc treatment should not be interrupted if alcohol is consumed.
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