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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: May 9, 2026

Screening Ion Channels in Cancer Cells
06:19

Screening Ion Channels in Cancer Cells

Published on: June 16, 2023

Membrane potential and cancer progression.

Ming Yang1, William J Brackenbury

  • 1Department of Biology, University of York York, UK.

Frontiers in Physiology
|July 25, 2013
PubMed
Summary

Membrane potential (Vm) regulates cell activities. In cancer, a depolarized Vm promotes proliferation and cancer stem cell emergence, suggesting Vm as a therapeutic target.

Area of Science:

  • Biophysics
  • Cell Biology
  • Oncology

Background:

  • Membrane potential (Vm) is crucial for cellular functions, regulated by ion channels and transporters.
  • Cancer cells exhibit distinct bioelectrical properties, often characterized by a depolarized Vm.
  • Vm influences cell proliferation, migration, and differentiation, with implications for cancer stem cells (CSCs).

Purpose of the Study:

  • To review the role of Vm as a bioelectrical signal in cancer.
  • To examine key ion channels regulating Vm in cancer cells.
  • To discuss Vm's impact on cancer cell proliferation, migration, and differentiation.

Main Methods:

  • Literature review of studies on Vm in cancer.
  • Analysis of ion channel/transporter functions in regulating Vm.
Keywords:
cancercell cycledifferentiationion channelmembrane potentialmigrationproliferationstem cell

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Last Updated: May 9, 2026

Screening Ion Channels in Cancer Cells
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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
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Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

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  • Examination of Vm's role in cancer cell behavior and CSCs.

    • Main Results:

    • Depolarized Vm is common in cancer cells, promoting proliferation.
    • Vm levels are critical for cancer cell migration and stemness.
    • Hyperpolarization is essential for normal stem cell differentiation.

    Conclusions:

    • Vm is a significant bioelectrical regulator in cancer.
    • Targeting Vm may offer novel strategies for cancer therapy and detection.
    • Further research into Vm's clinical applications in oncology is warranted.