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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...

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Related Experiment Video

Updated: May 9, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap² Method

Published on: May 21, 2018

Moxifloxacin-warfarin interaction.

Yan Ji¹, Youssef Hokayem

¹Department of Medicine, Union Memorial Hospital, Baltimore, MD, USA.

Journal of Community Hospital Internal Medicine Perspectives

|July 25, 2013

Summary

This summary is machine-generated.

Warfarin and moxifloxacin coadministration can elevate prothrombin time/international normalized ratios (PT/INR). Healthcare providers should monitor INR closely in patients on warfarin, particularly those with low albumin, when prescribing moxifloxacin.

Keywords:

PT/INR hypoalbuminemia moxifloxacin warfarin

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Area of Science:

Pharmacology
Drug Interactions
Clinical Medicine

Background:

Warfarin is a widely prescribed anticoagulant.
Moxifloxacin is a fluoroquinolone antibiotic.
Drug interactions can alter therapeutic efficacy and safety.

Observation:

Two case reports detail elevated prothrombin time/international normalized ratios (PT/INR).
These elevations occurred after coadministration of warfarin and moxifloxacin.
Low albumin levels were noted in affected patients.

Findings:

A potential interaction exists between warfarin and moxifloxacin.
The precise mechanism of this interaction is currently unknown.
Elevated PT/INR suggests increased anticoagulation effect.

Implications:

Healthcare providers must exercise caution when prescribing moxifloxacin to patients on warfarin.
Increased vigilance and frequent INR monitoring are recommended for patients with low albumin levels.
This interaction highlights the importance of comprehensive drug interaction surveillance.