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Osteoporosis in celiac disease: a Hispanic pilot study

Joel Ojeda-Rivera1, Bárbara Rosado Carrión, Osvaldo Antommattei Frontera

  • 1Internal Medicine Department of the Damas Hospital and Ponce School of Medicine, Ponce, Puerto Rico. damasmed@gmail.com

Boletin De La Asociacion Medica De Puerto Rico
|July 26, 2013
PubMed

Insights

Celiac disease (CD) is linked to lower bone density in Hispanic women. This study in Puerto Rico highlights the need for bone health monitoring in CD patients, especially women.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Bone Metabolism

Background:

  • Osteoporosis and osteopenia are global health concerns.
  • Celiac disease (CD) is associated with reduced bone density in various populations.
  • Limited data exists on bone density in Hispanic populations with CD.

Purpose of the Study:

  • To investigate the association between Celiac disease and decreased bone density (osteoporosis, osteopenia) in the Hispanic population of southern Puerto Rico.
  • To describe clinical manifestations of CD in this demographic.
  • To compare Dual-energy X-ray absorptiometry results.

Main Methods:

  • Retrospective record review of Celiac disease patients at a Gastroenterology Clinic.
  • Analysis of Dual-energy X-ray absorptiometry (DXA) scans.
  • Evaluation of clinical manifestations and laboratory markers (hemoglobin, TSH, 25-hydroxyvitamin D, IgA).

Main Results:

  • Seven Celiac disease patients were analyzed; 86% were female, with an average age of 46.
  • Most patients were overweight (BMI 29).
  • CD patients exhibited abnormalities in hemoglobin, TSH, and 25-hydroxyvitamin D. High IgA screening markers were noted, with a 90% association strength between IgA and TSH. Significantly lower bone density was observed in 86% of female CD patients.

Conclusions:

  • Celiac disease in Hispanic women is associated with lower bone density.
  • A higher prevalence of osteopenia was observed in women with Celiac disease.
  • Osteoporosis was not specifically prevalent in this cohort, but osteopenia was significant.
Abstract

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