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Related Experiment Video

Updated: May 9, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

Oligonucleotide conjugates for therapeutic applications.

Johannes Winkler¹

¹Department of Medicinal Chemistry, University of Vienna, Vienna, Austria. johannes.winkler@univie.ac.at

Therapeutic Delivery

|July 26, 2013

Summary

This summary is machine-generated.

Oligonucleotide conjugates, with attached ligands, improve therapeutic delivery by enhancing cellular uptake and pharmacokinetic properties, overcoming key development hurdles.

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Published on: March 6, 2019

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Last Updated: May 9, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Published on: March 6, 2019

Area of Science:

Biochemistry
Medicinal Chemistry
Drug Delivery

Background:

Oligonucleotide therapeutics face challenges with poor pharmacokinetics and cellular uptake.
Ligand conjugation offers a strategy to improve biodistribution and tissue targeting.

Purpose of the Study:

To review current developments in therapeutic oligonucleotide conjugates.
To summarize ligand types, linkage strategies, and their impact on oligonucleotide properties.

Main Methods:

Review of scientific literature on oligonucleotide conjugation.
Analysis of various attached ligands (peptides, proteins, carbohydrates, aptamers, small molecules).
Summary of conjugation techniques and linkage chemistries.

Main Results:

Oligonucleotide conjugates are defined molecules, facilitating analytics and quality control.
Attached ligands significantly influence pharmacokinetic parameters and cellular uptake mechanisms.
Diverse ligands like cholesterol and folic acid enhance therapeutic potential.

Conclusions:

Oligonucleotide conjugation is a promising approach to overcome delivery barriers for oligonucleotide therapeutics.
Ligand selection and conjugation strategy are critical for optimizing drug performance.
This method expands therapeutic options and development avenues for oligonucleotide agents.