Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early prophylactic antibiotics effect on infection rate in blunt open fractures.

Journal of orthopaedic surgery and research·2026
Same author

Cultural Adaptation and Pilot Implementation of Education in Palliative and End-of-Life Care for Emergency Physicians (EPEC-EM) for Emergency Medicine Practice in Japan.

Journal of palliative medicine·2026
Same author

Integrating Palliative Care in End-Stage Liver Disease: An Interprofessional Perspective on Communication, Terminology, and Educational Gaps.

Journal of palliative medicine·2026
Same author

Reply.

Journal of vascular surgery·2026
Same author

The Validity of Frailty Scoring in Preoperative Risk Assessment for Patients in the Surgical Intensive Care Unit.

The Journal of surgical research·2025
Same author

Adapting Palliative and End-of-Life Care Training for Emergency Physicians in Japan: A Modified Grounded Theory Study.

AEM education and training·2025

Related Experiment Video

Updated: May 9, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Inflammatory processes in complex regional pain syndromes.

Joshua Hauser1, Bernard Hsu, Nader D Nader

  • 1School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.

Immunological Investigations
|July 26, 2013
PubMed
Summary

Chronic Regional Pain Syndrome (CRPS) involves unclear pathophysiology. This review synthesizes current data on inflammatory cytokines and mediators in the central and peripheral nervous systems contributing to CRPS development and progression.

Related Experiment Videos

Last Updated: May 9, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Area of Science:

  • Neuroscience
  • Immunology
  • Pain Medicine

Background:

  • Chronic Regional Pain Syndrome (CRPS), formerly reflex sympathetic dystrophy, is increasingly recognized.
  • Current understanding of CRPS etiology, pathogenesis, and treatment is evolving.
  • Significant gaps remain in knowledge regarding the pathophysiology and mechanisms driving CRPS progression.

Purpose of the Study:

  • To synthesize current theories and data on the role of inflammatory mediators in CRPS.
  • To elucidate the contribution of central and peripheral nervous system factors to CRPS development.
  • To present a comprehensive overview of inflammatory cytokines in CRPS pathogenesis.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies investigating inflammatory cytokines and other mediators.
  • Examination of evidence related to the central and peripheral nervous systems in CRPS.

Main Results:

  • Inflammatory cytokines and mediators play a significant role in CRPS.
  • Both central and peripheral nervous system pathways are implicated in CRPS.
  • Specific mediators contribute to the development and progression of CRPS symptoms.

Conclusions:

  • Inflammatory processes are central to CRPS pathophysiology.
  • Targeting inflammatory pathways may offer therapeutic strategies for CRPS.
  • Further research is needed to fully understand the complex mechanisms of CRPS.