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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Inflammatory Bowel Disease II: Crohn's Disease

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Published on: December 15, 2011

Current trends and investigative developments in celiac disease.

Gabriel Samaşca1, Genel Sur, Iulia Lupan

  • 1Department of Immunology, "Iuliu-Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Gabriel.Samasca@umfcluj.ro

Immunological Investigations
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Advances in celiac disease diagnosis and understanding of gluten toxicity have spurred the development of novel therapies beyond the gluten-free diet. Research explores new treatments to address the increasing prevalence and impact of this immune-mediated enteropathy.

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Published on: September 13, 2016

Area of Science:

  • Immunology
  • Gastroenterology
  • Celiac Disease Research

Background:

  • Celiac disease is an immune-mediated enteropathy with diverse clinical presentations, affecting any organ system.
  • Improved diagnostic accuracy, particularly with serological tests like tissue transglutaminase and endomysial antibodies, has revealed a higher prevalence.
  • The effectiveness and quality of life impact of the gluten-free diet are increasingly questioned, necessitating alternative treatments.

Purpose of the Study:

  • To review recent investigative developments in celiac disease.
  • To assess the need for new treatment modalities in celiac disease.
  • To present emerging therapies and diagnostic advancements.

Main Methods:

  • Review of serological diagnostic advancements, including antibodies against deamidated gliadin peptides.
  • Exploration of new gluten toxicity screening methods (e.g., K562(S)-cell agglutination, monoclonal antibodies, proteomics).
  • Investigation into novel therapeutic strategies such as TG2 inhibitors and experimental copolymers.

Main Results:

  • Serological tests have significantly improved celiac disease diagnosis and recognition of its prevalence.
  • New research into gluten toxicity mechanisms is driving the development of innovative treatments.
  • Emerging therapies aim to offer alternatives or adjuncts to the gluten-free diet.

Conclusions:

  • Celiac disease diagnosis and understanding have evolved significantly, highlighting its non-rare status.
  • The limitations and impact of the gluten-free diet warrant the exploration of new therapeutic avenues.
  • Ongoing research into disease mechanisms and novel treatments is crucial for managing celiac disease effectively.