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Updated: May 9, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Anterior uveitis secondary to type II essential cryoglobulinemia
Laura Nicholson1, Lucia Sobrin
1Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Lucia_Sobrin@meei.harvard.edu.
Background:
The purpose of this report is to describe the association of severe anterior uveitis with type II essential cryoglobulinemia.
Findings:
A 40-year-old male with a history of psoriatic arthritis presented with severe anterior uveitis associated with type II essential cryoglobulinemia. His uveitis, refractory to steroid treatments, was well controlled following treatments for cryoglobulinemia. The temporal association between his cryoglobulinemia and uveitis, combined with his improved visual acuity and inflammation after plasmapheresis and rituximab infusions, suggests cryoglobulinemia to be the underlying condition of his uveitis.
Conclusions:
To our best knowledge, this is the first reported case of anterior uveitis secondary to type II essential cryoglobulinemia.
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