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Updated: May 9, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

A fiber-based implantable multi-optrode array with contiguous optical and electrical sites.

Sanyuan Chen¹, Weihua Pei, Qiang Gui

¹State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, People's Republic of China.

Journal of Neural Engineering

|July 26, 2013

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We developed a novel optrode array for precise neural modulation. This device integrates optical stimulation and electrophysiological recording, enabling advanced brain-computer interfaces and neural prosthetics.

Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Existing optrodes often have a large separation between optical and electrical sites, blurring stimulation precision.
This limits the accuracy of light intensity thresholds and stimulation localization.

Purpose of the Study:

To develop a novel optrode array with integrated optical delivery and electrophysiological recording sites.
To reduce the spatial gap between optical and electrical components for enhanced precision.

Main Methods:

Fabrication of a coniform-tipped optical fiber optrode with a gold membrane electrode.
Integration of optrodes into a multi-optrode array (MOA) using a mechanical transfer (MT) connector.
Validation in ChR2-expressing mouse cortex, monitoring neuronal responses to optical stimulation.

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Last Updated: May 9, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

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Main Results:

A lightweight, pluggable MOA was fabricated with a precise metal membrane electrode cover.
The optrode demonstrated an average electrochemical impedance of 100 kΩ at 1 kHz and light emission up to 13 mW.
Successful monitoring of neuronal activity with high signal-to-noise ratio (5:1) and coherence during 20 Hz stimulation.

Conclusions:

The developed optrode array significantly reduces the distance between optical and electrophysiological sites.
This novel structure offers multi-channel simultaneous light delivery and precise neural modulation.
The device shows potential for advanced optical neural control prosthetic devices and brain modulation therapies.