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Related Concept Videos

Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Exercise-induced bronchospasm, asthma control, and obesity.

Nancy K Ostrom1, Jonathan P Parsons, Nemr S Eid

  • 1Allergy and Asthma Medical Group and Reasearch Center, San Diego, California, USA.

Allergy and Asthma Proceedings
|July 26, 2013
PubMed
Summary
This summary is machine-generated.

Poorly controlled asthma is common in children and adults. Exercise-induced bronchospasm (EIB) and respiratory symptoms are more frequent in those with uncontrolled asthma. Obesity is also linked to poorly controlled asthma in adolescents and adults.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 4, 2010

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

Area of Science:

  • Pulmonology
  • Pediatric Asthma Research
  • Obesity and Respiratory Health

Background:

  • Exercise-induced bronchospasm (EIB) is prevalent in asthma patients, but its link to asthma control and obesity is not well understood.
  • Asthma management and its impact on physical activity levels, particularly concerning obesity, require further investigation.

Purpose of the Study:

  • To reanalyze survey data to determine the relationship between EIB, asthma control, and obesity in a diverse asthma patient population.
  • To assess the prevalence of EIB and exercise-related respiratory symptoms in relation to asthma control across different age groups.

Main Methods:

  • A nationwide telephone survey interviewed 250 children, 266 adolescents, and 1001 adults with asthma.
  • Data collected included general asthma symptoms, medication use, height, weight, and history of EIB.
  • Asthma control was assessed using Expert Panel Report 3 criteria, and obesity was defined as BMI ≥ 30 kg/m².

Main Results:

  • A high percentage of participants (77.6% children, 71.1% adolescents, 83.1% adults) had poorly controlled asthma.
  • Patients with poorly controlled asthma reported significantly more EIB and exercise-related respiratory symptoms.
  • Obesity was more prevalent in adolescents and adults with poorly controlled asthma, but not in children.

Conclusions:

  • Most children, adolescents, and adults with asthma have poorly controlled disease.
  • EIB and exercise-related symptoms are strongly associated with suboptimal asthma control.
  • Obesity is linked to poorly controlled asthma in adolescents and adults, highlighting a need for integrated management strategies.