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Cabergoline therapy for Cushing disease throughout pregnancy
Irene Woo1, Robert M Ehsanipoor
1Department of Gynecology and Obstetrics and Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Obstetrics and Gynecology
|July 26, 2013
Summary
Cabergoline effectively manages Cushing disease in pregnant women, even after surgery failure. This dopamine agonist offers a safe and successful treatment option, leading to a healthy pregnancy and delivery.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Pharmacology
Background:
- Cushing disease in pregnancy presents rare but severe risks to both mother and fetus.
- Transsphenoidal pituitary surgery is the primary treatment, but medical management is crucial for non-surgical candidates or treatment failures.
Observation:
- A 29-year-old woman with Cushing disease, whose prior surgery was unsuccessful, received high-dose cabergoline therapy.
- She conceived and continued cabergoline throughout her pregnancy, experiencing an uncomplicated course.
- The patient delivered a healthy neonate at 38 weeks gestation.
Findings:
- Cabergoline, a dopamine agonist, demonstrated successful management of Cushing disease during pregnancy.
- High-dose cabergoline administration was well-tolerated throughout gestation.
Implications:
- Cabergoline represents a viable medical therapy for Cushing disease in pregnant patients.
- This approach offers a favorable outcome for maternal and fetal health in challenging cases.
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