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Related Experiment Video

Updated: May 9, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Filovirus entry.

Graham Simmons¹

¹Department of Laboratory Medicine, University of California, San Francisco, CA, USA. gsimmons@bloodsystems.org

Advances in Experimental Medicine and Biology

|July 26, 2013

Summary

This summary is machine-generated.

Recent advances enhance understanding of filovirus attachment and cellular tropism. Key host factors like Niemann-Pick C1 are vital for filovirus entry and membrane fusion.

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In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

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Area of Science:

Virology
Cell Biology
Molecular Biology

Background:

Filovirus attachment and cellular tropism are critical for infection.
Previous models of viral entry, such as for HIV and influenza, provide a basis for understanding filovirus mechanisms.

Purpose of the Study:

To summarize recent advances in understanding filovirus attachment and cellular tropism.
To highlight the roles of specific host cell factors in filovirus entry and fusion.

Main Methods:

Literature review of recent studies on filovirus-host interactions.
Analysis of identified cell-surface attachment factors.
Examination of host cell factors involved in viral entry and membrane fusion.

Main Results:

Several cell-surface molecules identified as attachment factors for targeting specific cells (e.g., macrophages, hepatic cells).
New insights into filovirus internalization and entry pathways, diverging from established viral entry paradigms.
Host cell factors, including endosomal proteases and Niemann-Pick C1, confirmed as crucial for activating filovirus glycoprotein-mediated membrane fusion.

Conclusions:

Significant progress has been made in understanding filovirus attachment and tropism.
Host cell factors play indispensable roles in mediating filovirus entry and fusion, offering potential therapeutic targets.