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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Sevoflurane therapy for life-threatening asthma in children

D Schutte1, A M Zwitserloot, R Houmes

  • 1Department of Intensive Care Medicine and.

British Journal of Anaesthesia
|July 26, 2013
PubMed

Insights

Sevoflurane inhalation therapy effectively treated severe asthma in mechanically ventilated children. This treatment improved carbon dioxide levels and clinical status in pediatric intensive care unit patients.

Area of Science:

  • Pediatric critical care medicine
  • Respiratory medicine
  • Pharmacology

Background:

  • Asthma is a prevalent childhood respiratory condition with early onset.
  • Severe asthma exacerbations in children necessitate intensive care.
  • This study investigates sevoflurane inhalation therapy for severe pediatric asthma.

Purpose of the Study:

  • To evaluate the effectiveness of sevoflurane inhalation therapy.
  • To assess clinical outcomes in children with severe asthma requiring mechanical ventilation.
  • To explore sevoflurane's role in refractory pediatric asthma cases.

Main Methods:

  • A multicentre retrospective case series.
  • Inclusion of seven children (4-13 years) with severe asthma in the pediatric intensive care unit (PICU).
  • Treatment involved sevoflurane inhalation therapy during invasive mechanical ventilation.

Main Results:

  • Sevoflurane inhalation significantly reduced carbon dioxide levels (Pco2) and normalized pH.
  • Peak airway pressures decreased, indicating improved lung mechanics.
  • Hypotension was the main adverse effect, responsive to norepinephrine.

Conclusions:

  • Sevoflurane inhalation therapy is effective in correcting hypercapnia in mechanically ventilated children with severe asthma.
  • It provides clinical improvement for life-threatening asthma cases unresponsive to standard treatments.
  • Sevoflurane represents a viable therapeutic option for severe pediatric asthma.
Abstract

Keywords:
anesthetics, inhalationasthmapediatricssevoflurane

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