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[Peripheral T-cell lymphoma. Morphologic, immunophenotypic and immunogenotypic studies of 10 cases]
1Servicios de Hematología, de Anatomía Patológica, Hospital de la Santa Creu i Sant Pau, Barcelona.
Medicina Clinica
|May 19, 1990
Summary
This study details 10 peripheral T-cell lymphoma cases, revealing diverse histopathology and a mature T-cell phenotype. All cases confirmed T-cell receptor gene rearrangements, distinguishing them from B-cell malignancies.
Area of Science:
- Hematology
- Oncology
- Pathology
Context:
- Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas.
- Accurate classification and understanding of PTCL subtypes are crucial for diagnosis and treatment.
- Limited data exists on the comprehensive histopathological, immunophenotypic, and immunogenotypic profiles of diverse PTCL cases.
Purpose:
- To characterize the histopathology, immunophenotype, and immunogenotype of 10 PTCL cases.
- To classify PTCL subtypes based on histopathological features.
- To confirm the T-cell lineage of neoplastic cells and rule out B-cell origin.
Summary:
- Ten PTCL cases were analyzed, with most presenting with disseminated disease.
- Histopathological classification included T-zone lymphoma, Lennert lymphoma, and three types of pleomorphic lymphoma.
- Neoplastic cells exhibited a mature T-cell phenotype (CD3+, CD4+, CD8-, CD43+, CD45RO+) with T-cell receptor beta chain gene rearrangements, confirming T-cell origin.
Impact:
- Provides detailed characterization of rare PTCL subtypes.
- Reinforces the utility of combined histopathological and molecular analysis in PTCL diagnosis.
- Contributes to a better understanding of the T-cell lymphoma spectrum.