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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Published on: September 27, 2013

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Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?

Song Guo Zheng1

  • 1Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine Los Angeles, CA. 90033, United States.

American Journal of Clinical and Experimental Immunology
|July 26, 2013
PubMed

Naive CD4(+) cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3(+) regulatory T cells depending upon the presence of other cytokines. IL-6 promotes Th17, but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. Here an update of T cell differentiation and conversion, as well as underlying mechanisms are given.

Keywords:
Foxp3+ regulatory T cellsT helper cellsTfhTh1Th17Th2Th9autoimmunitycytokinedifferentiation

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