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Updated: May 9, 2026

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Critical limb ischemia
1Section of Vascular Surgery and Endovascular Therapy, The University of Chicago Medical Center, Chicago, IL 60637, USA. matthew.blecha@yahoo.com
Abstract:
Critical limb ischemia refers to the clinical state of advanced arterial occlusive disease, placing an extremity at risk for gangrene and limb loss. Critical limb ischemia has 2 broad clinical subcategories that are vital to differentiate: acute limb ischemia and chronic arterial occlusive disease. This article reviews the etiologies, diagnosis, and treatment of critical limb ischemia.
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