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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Steroid receptor coactivator-3 promotes bladder cancer through upregulation of CXCR4

Yu Zhang1, Ji-Hong Wang, Bin Liu

  • 1Department of Urology, Shanghai Changning Center Hospital, Shanghai, China. ping_baoqu@126.com

Asian Pacific Journal of Cancer Prevention : APJCP
|July 27, 2013
PubMed

Insights

SRC-3 (Steroid Receptor Coactivator-3) overexpression drives bladder cancer cell growth. Targeting SRC-3 and its downstream target CXCR4 may offer new bladder cancer prevention and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The p160 family of transcriptional coactivators, including SRC-3 (Steroid Receptor Coactivator-3), are crucial for nuclear receptor signaling.
  • SRC-3 amplification and overexpression are implicated in various human cancers, promoting cell proliferation and survival.
  • The specific role of SRC-3 in bladder cancer pathogenesis remains largely uncharacterized.

Purpose of the Study:

  • To investigate the role of SRC-3 in bladder cancer.
  • To identify molecular mechanisms by which SRC-3 influences bladder cancer progression.
  • To explore SRC-3 as a potential therapeutic target for bladder cancer.

Main Methods:

  • Utilized cell culture models of bladder cancer.
  • Manipulated SRC-3 expression levels (overexpression and knockdown).
  • Assessed the impact on cell proliferation and survival.
  • Performed molecular analyses to identify transcriptional targets of SRC-3.

Main Results:

  • SRC-3 overexpression significantly enhanced bladder cancer cell proliferation.
  • Knockdown of SRC-3 expression inhibited bladder cancer cell proliferation.
  • Identified CXCR4 as a direct transcriptional target of SRC-3 in bladder cancer cells.

Conclusions:

  • SRC-3 plays a critical role in promoting bladder cancer cell proliferation.
  • SRC-3's function in bladder cancer is mediated, in part, through the regulation of CXCR4.
  • SRC-3 represents a promising molecular target for bladder cancer prevention and treatment strategies.

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