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Updated: Aug 5, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific
1Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70179.
Abstract:
Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.
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