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Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...

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Related Experiment Video

Updated: May 9, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

Networking galore: intermediate filaments and cell migration.

Byung-Min Chung1, Jeremy D Rotty, Pierre A Coulombe

  • 1Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Current Opinion in Cell Biology
|July 27, 2013
PubMed
Summary

Intermediate filaments (IFs) are essential structural proteins that maintain cell integrity. This review explores how IFs, particularly vimentin and keratin, regulate cell migration through mechanical and regulatory pathways.

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In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Related Experiment Videos

Last Updated: May 9, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Area of Science:

  • Cell Biology
  • Biochemistry
  • Biophysics

Background:

  • Intermediate filaments (IFs) are conserved protein networks crucial for cellular and tissue integrity.
  • Mutations in IFs lead to various inherited clinical disorders, highlighting their importance.
  • IFs play roles in cellular responses to stress and adaptation.

Purpose of the Study:

  • To review the multifaceted roles of IFs in cell migration.
  • To focus on the specific contributions of vimentin and keratin to cell migration.
  • To elucidate how IFs impact cell mechanics, cytoarchitecture, adhesion, and regulatory pathways influencing migration.

Main Methods:

  • Literature review focusing on intermediate filaments, vimentin, and keratin.
  • Analysis of studies investigating the mechanical and regulatory functions of IFs in cellular processes.
  • Synthesis of findings related to IFs' impact on cell migration.

Main Results:

  • IFs significantly influence cell migration by modulating mechanical properties and cytoarchitecture.
  • Vimentin and keratin are key IF proteins impacting cell adhesion and regulatory pathways governing migration.
  • IFs act as both effectors and regulators in the complex process of cell migration.

Conclusions:

  • Intermediate filaments are critical regulators of cell migration.
  • Understanding IF function in migration is vital for addressing related clinical disorders.
  • Further research into IFs' roles in cell mechanics and regulation can yield therapeutic insights.